How They Differ
Semaglutide copies one gut hormone (GLP-1). Tirzepatide copies two (GLP-1 and GIP), which seems to add appetite control and metabolic benefit. Both are weekly injections with the same dose-step approach.
Results
In the direct comparison trial, tirzepatide led to about 20 percent weight loss at 72 weeks versus about 14 percent for semaglutide. Semaglutide has published data showing fewer heart attacks and strokes in people with heart disease.
Side Effects
Similar lists: nausea, constipation, fatigue. Tirzepatide is often reported as a bit gentler on nausea at equivalent loss.
Cost
Brand: both around $1,000 a month or more without coverage. Compounded at Zen IV Spa: semaglutide $199, tirzepatide $299. Most people start on semaglutide and move to tirzepatide if they plateau or want more.
Choosing
More to lose, or diabetes in the family: tirzepatide. Budget, or heart disease history: semaglutide. Either way, labs at home and a provider who adjusts. Every prescription at Zen IV Spa is written by a licensed provider under our medical director after a free video consultation. Medication ships to your door anywhere in New York or New Jersey, and a nurse can come to your home for labs or a first dose.
Common Questions
Can I switch between them?+
Yes, with a provider mapping the dose.
Is tirzepatide worth the extra $100?+
If you have more than 40 pounds to lose or stalled on semaglutide, usually.
Which is safer?+
Comparable. Semaglutide has more years of data.
All treatments are medical services. Every guest is screened, and every treatment is provided only under the clearance, prescription or standing protocol of a licensed medical provider. Nothing on this page is a diagnosis or a promise of results. For an emergency, call 911.