The Mechanism
Receptors that are stimulated continuously are pulled inside the cell or produced in lower numbers. The same dose does less.
Which Peptides
Growth-hormone secretagogues (ipamorelin especially), PT-141 with frequent use, Semax/Selank daily for months. GLP-1s are designed for continuous use and do not desensitize in the same way.
Prevention
Five days on, two off for GH peptides; a month off every three to six; PT-141 no more than twice a week; Semax/Selank in blocks.
Common Questions
Signs it is happening?+
Benefits fading at the same dose.
Fix?+
A break, not a higher dose.
Does BPC-157 desensitize?+
Not meaningfully; it is cycled for other reasons.
All treatments are medical services. Every guest is screened, and every treatment is provided only under the clearance, prescription or standing protocol of a licensed medical provider. Nothing on this page is a diagnosis or a promise of results. For an emergency, call 911.