Metformin

Decades of data, pennies a month, FDA-approved for type 2 diabetes and used off-label for prediabetes and longevity. Side effects: GI upset, B12 depletion.

MOTS-c

A mitochondrial peptide that improves insulin sensitivity and exercise capacity in early studies. Compounded by prescription, $229 a month, two to three injections a week. Not FDA-approved.

Which

Prediabetes or diabetes: metformin, through your doctor. Metabolic support with training, or metformin intolerance: MOTS-c. Some use both.

Common Questions

Can you prescribe metformin?+

Yes, with labs.

Together?+

With provider guidance.

Which is safer?+

Metformin has far more data.

All treatments are medical services. Every guest is screened, and every treatment is provided only under the clearance, prescription or standing protocol of a licensed medical provider. Nothing on this page is a diagnosis or a promise of results. For an emergency, call 911.