What It Does

Lowers the liver's sugar output and improves insulin sensitivity. Mildly lowers appetite. Approved for type 2 diabetes; used off-label for prediabetes, PCOS and some weight goals.

Results

Two to three percent of body weight over a year in most studies. Better results in people with insulin resistance or PCOS. Not comparable to the 15 to 20 percent from GLP-1s.

Side Effects

Stomach upset and diarrhea early (extended-release helps). B12 depletion over years (we check it). Not for people with poor kidney function.

Where It Fits

Prediabetes or PCOS with modest weight goals. Alongside a GLP-1 for blood sugar. A low-cost maintenance tool after a GLP-1. We prescribe it after labs at your home.

Common Questions

Can I take metformin with semaglutide?+

Yes, common in diabetes and sometimes in weight programs.

Does it cause low blood sugar?+

Not on its own.

Is it good for longevity?+

Debated; the data is mixed in people without diabetes.

All treatments are medical services. Every guest is screened, and every treatment is provided only under the clearance, prescription or standing protocol of a licensed medical provider. Nothing on this page is a diagnosis or a promise of results. For an emergency, call 911.